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How to pronounce methotrexate in English. The definition of methotrexate is: toxic antimetabolite that limits cellular reproduction by acting as an antagonist.Ovary: Choriocarcinoma, Authors:. Combination chemotherapy with methotrexate, etoposide, and actinomycin D for high-risk gestational trophoblastic tumors.

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Inhibitors of folate biosynthesis. Sulfamethoxazole is used as a broad spectrum antibacterial, but, to avoid resistances, it is generally combined with.

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